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refactory depression?

I have a complex mix of disorders that my doctors are finding difficult to treat (Tourette's, OCD, anxiety/panic attacks, depression/possibly bipolar/they can't decide due to all my other symptoms). SSRIs had no noticeable effect (I've tried Paxil, Zoloft, Lexapro & Prozac), antipsychotics are a big no due to cognitive side effects (Haldol, Seroquel, Zyprexa, Orap), Effexor and Remeron leveled out quickly even at top doses (and Effexor makes me hallucinate), and Wellbutrin worked okay but makes Tourette's tics difficult to manage.For those of you that didn't respond to SSRIs, what actually worked for you?I've tried benzos as well. Xanax works great for anxiety (and Tourette's), I took it previously for a couple of years alongside a few other meds. I'm in a new country now though, and they don't want to prescribe them longterm, so it's not an option.I've been off meds completely for 1.5 years, and I'm doing badly which is why the doctors want to put me back on something.. they just don't know what to try. Depression and agoraphobia is currently so severe I haven't left home in 3 months except to go to the doctor. My father died recently (taking care of him meant giving up my job as well), which leaves me back in a new country without a job and knowing no one.. but I don't have support elsewhere anyway so it doesn't matter where I am. I've done yoga and meditation for many years to help manage Tourette's, but right now something more is needed.



For those that don't respond to SSRIs, which antidepressant works best?

I was prescribed 50 mg/day Zoloft two days ago for severe depression and Klozapam (sp?) for anxiety. The anti-anxiety seems to be working ok. Im now terrified to take any medication because of a flare up of anxiety with Wellbutrin a few months back. I'm scared of something making me worse but the pain I feel from depression has made life unbearable. The first time I took the Zoloft two days ago I felt this rush of uncomfortable energy.... like similar to drinking 10 cups of coffee. I felt fidgety, shaky, and I couldnt sit still. My depression wasnt worse nor my anxiety but I understand Zoloft should have a calming/drowsy effect when first taking it, not the opposite. I just hope its not sending me into what the doctor called "a manic episode." He said I dont sound bipolar so Im just not sure. His nurse said to keep taking it a few more days. Anybody else out there have a similar experience anddid these symptoms go away? Thanks



Fidgety/hyperness on Zoloft?

I am Bipolar 2, rapid cycling. I'm still depressed and still have anxiety, and when I socialize I sometimes still become fixated on people and think people are talking about me.I'm thinking maybe Abilify would be good to try, but my Doc is recommending Zoloft.Any opinions appreciated?



What is a good add-on to 300mg Lamictal and 150mg Wellbutrin?

I'm 20, been depressed/anxious my entire life, diagnosed with Bipolar when I was 12. Seen upwards of 7 psychiatrists, 5 psychologists (DBT, CBT, etc). Diagnosed with Treatment Resistant Bipolar 1 Rapid Cycling Not Otherwise Specified. Lithium's pretty good with the mania but nothing has ever been able to treat the depression. It's taken over my life and I just want hope that one day this illness will not dictate everything I do. My doctors are just blindly guessing at this point and a lot of them will just decline to treat me because they don't know what to do.Here is what I am taking currently:LithiumLamictalAbilifyKlonopinN Acetyl CysteineHere's what I've taken in the past: Zoloft, Trazodone, Zyprexa, Neurontin, Inositol, Depakote, Paxil, Wellbutrin, Lithium, Xanax, Valium, Seroquel, Lamictal, Lorazepam, Prozac, Ambien, Strattera, Lunesta, Melatonin, Abilify, Cytomel, Cymbalta, Provigil, Fish Oil, Effexor, Lexapro, Buspar, Rozarem, Geodon, EmsamI try so hard to fight this. I'm educated, knowledgeable, read books and medical papers about anything relating to my illness. I want to be better; there are periods when I think I am but then I cycle back down. There is just something messed up in my brain and I don't know what it is.Can anyone give me any kind of hope? Has anyone been through this? Does anyone know of something that could help me? I want to be able to go to school and have friends and get out of bed. I'm smart, I'm creative, I work hard, but the only thing that I ever get to talk or think about is medication.Please don't tell me to go off my medication, I've tried that and it doesn't have good results. I need SOMETHING. I'm willing to give you copies of my med records, lab work, detailed accounts of my history, med reactions, anything. I know this is sort of a stupid way to go about this but I feel like I've exhausted all my options.Please help me. I am desperate. I don't know what to do.I've tried ECT but I have to go off of Lamictal and Klonopin to do it and I end up much worse off than I was before.



Any hope for treatment refractory bipolar disorder?

I have been diagnosed with manic depression and bipolar. I have taken every medication under the sun (wellbutrin, prozac, zoloft, lexapro, cylexa...) the list goes on and nothing ever changes. I can't keep a job stay in college and I'm always crying or getting irritated.What the hell is wrong with me? I am at my wits end.



Please help me with my depression?

I have taken anti depressants in the past like Wellbutrin and prozac but I was irritable and anxious when taking them. Has anyone had good luck with any specific antidepressant? I am not bipolar in case anyone wonders that. Depression is something I have struggled with but with all the stress in my life right now I cannot seem to snap out of it. I get mad easily, am moody, irritable and cannot stand myself because of this. It is effecting my relationship with my husband, my children, immediate family, and my friends. I am closing everyone out of my life. Right now I take 50mg zoloft for anxiety but over the years I have had to increase it and now it doesn't seem to have any affect. I just had a hysterectomy of the uterus due to 7 fibroid tumors and my gyno said he may have to take my ovaries if I keep feeling so moody? huh has anyone heard of this. Simply put I want to be happy. I walk for excercise, do wieght training too, eat good, but I have a terrible time sleeping. I take Lunesta but now that doesn't always work so I take xanax too, then at times I have to take benadryl just to fall asleep. I need help. Any suggestions.? I do talk to my Dr. both famiy and gyno but neither has any answers



Suggestions on medication for depression

Why do we think it's okay to give barely understood psychotropic meds to people-including children-for issues that are often misdiagnosed?What is with the current trend to label parolees as bipolar and medicate the? Do you feel that chemicals such as Wellbutrin, Paxil, Zoloft, and the others, which can have horrific side effects, are REALLY better than an herbal remedy like marijuana which infact aids in relaxation and stimulates creativity and other positive feelings? Why are we so against testing herbal remedies?



Whats with all the sudden mental illness?

I have been on 25mg of Zoloft and 150mg of Wellbutrin XL for a little over a month now for depression. And ever since I started them, I've been having alot of mood swings. One day I'll be full of energy, super happy and really hyper and I won't need any sleep. Then a few days later I'll be exahusted and depressed. Could this maybe be bioplar disorder?



Could it be bipolar?

I've taken anti-depressants for 15+ years. I started with Zoloft; had great results at first and it sort of died out. I've been taking Wellbutrin and Lexapro for the past several years and all I can say is that I'm not in the morgue. I have no motivation to get anything started or done. I lost my job because I was always calling in sick because of my listlessness and general malaise. I am seeing a psychdoc and therapist. It helps on the days I go to my appts but then I go back to sleeping 12 to 18 hrs a day. On these days I feel good and energetic. I think I may manic (bipolar) but I'm never extreme so I don't know. I just read a website about a 3-minute cure for depression: something about a switch in your brain that turns off depression. Anyone heard of that?



Is anyone taking anti-depressants who is still lethargic, but not suicidal?

I have been diagnosed with bipolar depression, I now take 500 mg. of depakote in the morning with 150 mg. wellbutrin. In the evening I take 500 mg of depakote and 200 mg. of zoloft. In the last four months I've been having tremors, is that because of my medicine?